A prolonged bleeding time with a normal platelet count indicates all of the following EXCEPT which one?

A prolonged bleeding time with a normal platelet count can point to various conditions related to platelet function or vascular integrity. In this case, the exception is Bernard-Soulier syndrome.

Bernard-Soulier syndrome is characterized by a defect in platelet aggregation due to a deficiency in glycoprotein Ib-V-IX complex, which is essential for platelet adhesion. This defect often leads to thrombocytopenia, meaning that individuals typically present with a low platelet count, which would not align with the scenario described in the question where the platelet count is normal.

On the other hand, conditions like von Willebrand's disease and Glanzmann's disease often present with normal platelet counts but can lead to prolonged bleeding times. Von Willebrand's disease affects platelet function due to a deficiency in von Willebrand factor which aids in platelet adhesion, while Glanzmann's disease results from a lack of glycoprotein IIb/IIIa, affecting platelet aggregation, both causing prolonged bleeding time despite having a normal platelet count. Aspirin ingestion impairs platelet function by inhibiting cyclooxygenase, which also results in prolonged bleeding time without affecting the platelet count.

Thus, the key differentiator for the question is that Bernard-Soulier syndrome typically involves a