Acute lymphocytic leukemias that have a predominance of homogenous cells with a high N/C ratio belong to which FAB group?

Acute lymphocytic leukemias characterized by a predominance of homogeneous cells with a high nuclear-to-cytoplasmic (N/C) ratio are classified under the FAB L1 group. This classification reflects the morphological appearance of the leukemic cells, which appear small with scant cytoplasm and a high N/C ratio, indicative of immature lymphoblasts.

In the L1 category, the cells typically show little variation in size and nuclear shape, creating a uniform appearance. This is important in distinguishing it from other categories where the cells may exhibit more heterogeneity or larger individual cell sizes, as seen in L2 and L3 classifications, which represent mixed lineage and Burkitt-type leukemias, respectively.

Understanding these distinctions is crucial for accurate diagnosis and subsequent treatment decisions in acute lymphoblastic leukemia cases.