All of the following sources of error will falsely elevate the ESR EXCEPT which one?

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In the context of the erythrocyte sedimentation rate (ESR) testing, it is crucial to identify factors that can lead to erroneous results. The ESR is influenced by the presence and characteristics of red blood cells (RBCs), as well as the conditions under which the test is performed.

Polycythemia refers to an increased concentration of red blood cells within the bloodstream. This condition typically results in a slower sedimentation rate because the elevated RBC mass makes them more viscous and less likely to settle rapidly. In essence, polycythemia does not falsely elevate the ESR; rather, it can actually lead to a lower reading because the increased number of RBCs interferes with the sedimentation process.

Other factors mentioned in the options contribute to false elevations in the ESR. A tilted tube can cause erratic results due to improper alignment, affecting the sedimentation process and yielding falsely high readings. Macrocytes, which are abnormally large red blood cells, tend to settle more slowly than normal-sized red blood cells, which can also result in an elevated ESR. Lastly, vibrations from a nearby centrifuge can disturb the sedimentation process, causing the cells to settle incorrectly and falsely elevate the ESR results.

Thus, understanding how polycy

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