If cryoglobulin is causing WBC cellular interference, what is the best way to resolve this issue?

When dealing with cryoglobulinemia, which involves the presence of cryoglobulins in the blood that can precipitate at lower temperatures, incubating the specimen at 37 degrees Celsius for 15 minutes is an effective approach to resolve WBC cellular interference. This temperature is optimal to maintain the solubility of cryoglobulins, preventing them from causing clumping or interference with white blood cell counts.

The process of warming the specimen allows the cryoglobulins to dissolve back into the serum, minimizing their impact on laboratory results. This step is critical, as accurate white blood cell counts are essential for proper diagnosis and treatment.

Other methods, such as incubating at room temperature, may not sufficiently address the solubility of cryoglobulins, and heating to 60 degrees Celsius could potentially damage cells and compromise the integrity of other analytes. Freezing the specimen overnight would exacerbate the issue by encouraging the formation of cryoglobulins, leading to further complications in the analysis.