Most chronic lymphocytic leukemias are neoplasms of which subset of lymphocytes?

Chronic lymphocytic leukemia (CLL) is primarily associated with the abnormal proliferation of B cells, a type of lymphocyte. In CLL, these B cells typically exhibit specific characteristics such as the expression of certain surface markers, which helps distinguish them from other types of lymphocytes.

B cells are responsible for producing antibodies and are a crucial part of the adaptive immune response. In CLL, the accumulation of abnormal B cells occurs, which can lead to a variety of complications, including affecting the body's ability to fight infections and causing other hematological issues due to the overcrowding of the bone marrow and alterations in normal blood cell production.

Understanding the specific lineage of the cells involved in CLL is essential for diagnosis and treatment, making the identification of B cells as the primary neoplastic population significant in the context of this leukemia type.