Results showing NASDA 3+ blasts and NASDA with sodium fluoride 1+ are consistent with which type of leukemia?

The presence of NASDA 3+ blasts and NASDA with sodium fluoride at 1+ provides specific information regarding the type of leukemic cells present. In the context of acute myelomonocytic leukemia (AMML), there is a notable characteristic related to the maturation of both myeloid and monocytic lineages.

In AMML, the blasts comprising both myeloid and monocytic features are expected to be present in significant numbers, often leading to a higher NASDA rating, which indicates an increased level of activity in these cells. The grading of NASDA reflects the degree to which these cells are present and can distinguish AMML from other forms of leukemia based on their respective characteristics.

In particular, the 3+ blasts indicate a predominant population of immature cells that is typical of acute leukemia, especially of the myelomonocytic type, highlighting the dual lineage involvement. The 1+ result when sodium fluoride is applied signifies that the leukemic cells, in this case, possess certain enzymatic properties that can be modified under different conditions, again supporting the diagnosis of AMML.

Understanding these markers and their relevance enables accurate classification of leukemia types, leading to appropriate clinical management and treatment strategies.