What cellular feature is indicative of Pelger-Huet anomaly?

The Pelger-Huet anomaly is characterized by an abnormality in the nuclear appearance of neutrophils and is specifically indicated by bi-lobed nuclei. In this condition, neutrophils, which are normally multi-lobed, typically exhibit nuclei that are either single-lobed or appear as two connected lobes, resembling a "dumbbell" shape. This phenomenon results from a genetic mutation that affects the maturation of granulocytes, leading to the unique nuclear morphology observed in affected individuals.

In contrast to the features indicated by the other options, such as hypersegmented nuclei (which are often seen in megaloblastic anemia), the presence of Dohle bodies (which are small light blue cytoplasmic inclusions indicative of stress or infection), and vacuolization (which can indicate cell death or damage), bi-lobed nuclei are distinctly the hallmark of Pelger-Huet anomaly. This characteristic makes it essential for clinical pathologists and hematologists to recognize, as it can aid in the diagnosis and differentiation of this benign condition from other more serious pathological processes.