What characterizes the blood smear of a patient with Hemoglobin C?

The blood smear of a patient with Hemoglobin C is characterized by the presence of target cells and microspherocytes. Target cells, also known as codocytes, appear as a central area of hemoglobin surrounded by a clear zone and then an outer ring of hemoglobin. This morphology arises due to the abnormal hemoglobin characteristics and the changes in the membrane structure of the red blood cells typical in various hemoglobinopathies, including Hemoglobin C.

Microspherocytes are small, round red blood cells that lack the typical biconcave shape and can occur due to various reasons, including unstable hemoglobin conditions. In the context of Hemoglobin C disease, the abnormal globin chains lead to membrane damage and, subsequently, to the formation of these microspherocytes.

In summary, the distinctive features of target cells and microspherocytes in the blood smear are indicative of the underlying pathophysiology in patients with Hemoglobin C, making it the correct response. Understanding these terms and their implications is vital for recognizing and interpreting hematological disorders.