What is the average lifespan of an erythrocyte?

The average lifespan of an erythrocyte, or red blood cell, is approximately 120 days. This is a well-established fact in hematology, as erythrocytes are produced in the bone marrow and released into the bloodstream where they exist for a finite period before being removed by the spleen and liver.

The lifespan of 120 days allows sufficient time for erythrocytes to perform their primary function of transporting oxygen from the lungs to tissues and carbon dioxide from the tissues to the lungs. After this period, the cells undergo senescence, which is a natural aging process leading to their eventual removal from circulation. This lifespan is an important aspect of understanding red blood cell turnover and is relevant in diagnosing and managing various hematological conditions, as alterations in this lifespan can influence overall red blood cell levels and function.