What is the main clinical manifestation of chronic myelogenous leukemia?

Chronic myelogenous leukemia (CML) is characterized by the proliferation of myeloid cells, leading to a range of clinical manifestations. One of the hallmark features of CML is splenomegaly, which refers to an enlargement of the spleen. This occurs due to the accumulation of immature and abnormal white blood cells in the spleen as the disease progresses.

The spleen plays a significant role in filtering blood and managing blood cells, and in CML, the excessive production of these cells results in the organ becoming engorged. Patients often present with splenomegaly, which can be detected during a physical examination and can lead to discomfort or a feeling of fullness in the abdomen.

While fatigue, weight loss, and excessive bleeding are also common symptoms in various hematological conditions, the distinct feature of splenomegaly in the context of chronic myelogenous leukemia sets it apart as a primary clinical manifestation of this disease.