Which anomaly is characterized by bi-lobed nuclei?

The Pelger-Huet anomaly is characterized by bi-lobed nuclei. This genetic condition affects neutrophils, which are a type of white blood cell. In individuals with this anomaly, the nuclei of the neutrophils exhibit an unusual morphological feature where they appear as two lobes connected by a thin strand of nuclear material, giving them a distinct bi-lobed shape. This is different from the typical multi-lobed appearance of neutrophil nuclei found in healthy individuals.

The presence of bi-lobed nuclei in the Pelger-Huet anomaly can be mistaken for immature cells if not recognized properly, which can lead to misinterpretation in a complete blood count. The anomaly does not necessarily affect the function of the neutrophils, but it's essential for a medical technologist to identify it correctly to avoid diagnostic confusion.

In contrast, the other options describe different conditions that do not involve bi-lobed nuclei. For example, hypersegmentation refers to neutrophils with nuclei that are divided into more than five lobes, typically seen in megaloblastic anemia. May-Hegglin anomaly includes large platelets and thrombocytopenia alongside characteristic inclusions in white blood cells. Smudge cells, also known as basket cells, are associated with