Which coagulation factors are considered labile?

Labile factors in coagulation refer to those that are sensitive to temperature changes and can degrade or lose functionality when exposed to heat. Among the coagulation factors, Factors V and VIII are classified as labile factors. They are especially sensitive and can be easily inactivated when stored improperly or subjected to higher temperatures.

Factor V is involved in the conversion of prothrombin to thrombin, acting as a cofactor in the clotting process, while Factor VIII is crucial for activating Factor X in the intrinsic pathway and is significantly important in hemophilia A. Due to their sensitivity, it is essential to handle and store these factors carefully in laboratory settings to ensure accurate coagulation testing and analysis.

The other factors listed do not share this same level of sensitivity. Factor I (fibrinogen) and Factor II (prothrombin) are stable at room temperature, while Factors VII and X are more stable than V and VIII, and Factors III and IX are not classified as labile. This knowledge is critical for medical technologists when handling samples for coagulation studies.