Which hereditary platelet disorder is characterized by decreased platelet production accompanied by Dohle bodies in polymorphonuclear cells?

The condition characterized by decreased platelet production and the presence of Dohle bodies in polymorphonuclear cells is indeed May-Hegglin anomaly. This hereditary disorder involves a qualitative defect in platelets leading to thrombocytopenia, which is a lower than normal number of platelets.

In May-Hegglin anomaly, Dohle bodies, which are small, grayish-blue inclusion bodies found in the cytoplasm of neutrophils, are indicative of the disorder and are formed due to ribosomal RNA aggregates. The presence of these inclusion bodies is a key cytological finding in individuals with this condition.

In contrast, the other disorders mentioned do not typically involve Dohle bodies or are characterized by different hematological features. Amegakaryocytic thrombocytopenia is primarily associated with a lack of megakaryocytes in the bone marrow, leading to reduced platelet production but without the presence of Dohle bodies. Bernard-Soulier syndrome is characterized by a defect in platelet adhesion due to the absence of the glycoprotein Ib-IX-V complex but does not involve Dohle bodies. Glanzmann's thrombasthenia is highlighted by a defect in platelet aggregation due to the absence of glycoprotein IIb/