Which inhibitor is known to inactivate coagulation factors through phospholipoprotein components?

The correct choice involves the lupus-like anticoagulant, which is a type of inhibitor that can interfere with the coagulation process by inactivating certain coagulation factors. Lupus anticoagulants are typically immunoglobulins that react with phospholipid components in the coagulation cascade, particularly affecting the function of procoagulant proteins that are dependent on phospholipids for their activity. The presence of these antibodies can lead to a paradoxical increase in the risk of thrombosis, despite their role as anticoagulants when tested under standard laboratory conditions.

In contrast, Vitamin K is primarily involved in the synthesis of vitamin K-dependent coagulation factors, such as factors II, VII, IX, and X, and does not function as an inhibitor of coagulation factors. Antithrombin III is a serine protease inhibitor that helps regulate blood coagulation by inhibiting thrombin and factor Xa, but it does not inactivate factors through a mechanism involving phospholipids. Lastly, Protein C is an anticoagulant protein that works by inactivating factors Va and VIIIa, but it does not specifically involve phospholipoprotein components for its action as lupus anticoagulants do.

Thus, the lupus-like antico