Which of the following conditions may lead to the formation of teardrop cells on a blood smear?

Teardrop cells, or dacrocytes, are abnormally shaped red blood cells that often indicate underlying pathology, particularly related to bone marrow or hematopoietic disorders. Myelofibrosis, which is characterized by the replacement of bone marrow with fibrous tissue, can lead to the distortion of red blood cells as they are produced and enter the circulation. This distortion is what results in the characteristic teardrop shape.

In myelofibrosis, the structure of the bone marrow is compromised, leading to ineffective hematopoiesis. As the red blood cells are forced through a fibrotic environment, their shape can be altered, resulting in teardrop cells being prominent on a blood smear. This is a classic finding associated with the disease and is often used diagnostically to help identify myelofibrosis among other hematological conditions.

While other conditions can cause changes in blood cell morphology, teardrop cells are predominantly associated with myelofibrosis and are considered a hallmark of this disorder. This makes it crucial for distinguishing myelofibrosis from other conditions.