Which platelet disorder is associated with abnormal primary aggregation?

The correct answer is Glanzmann's disease, which is characterized by a defect in platelet aggregation due to abnormalities in the glycoprotein IIb/IIIa complex on the platelet membrane. This complex is essential for platelet-to-platelet adhesion during the formation of a platelet plug, a critical step in the coagulation cascade. In Glanzmann's disease, the inability of platelets to aggregate results in a tendency for excessive bleeding, as the formation of stable platelet aggregates is compromised.

In contrast to this condition, other disorders listed do not primarily affect the initial aggregation process in the same way. Bernard-Soulier syndrome is marked by a defect in glycoprotein Ib/IX/V, leading to impaired adhesion of platelets to the damaged endothelium rather than an aggregation malfunction. Wiskott-Aldrich syndrome, which is a more complex condition that involves immunodeficiency and thrombocytopenia, also does not specifically involve abnormal primary aggregation. von Willebrand's disease impacts the function of von Willebrand factor, which is crucial for the stabilization of factor VIII and platelet adhesion but does not primarily lead to impaired aggregation as seen in Glanzmann's disease. Thus, Glanzmann's disease is uniquely associated with abnormal primary