Which RBC inclusion is NOT visible with Wright stain?

Heinz bodies are inclusions that indicate damage to hemoglobin due to oxidative stress and are not readily visible with a Wright stain. These bodies are formed from denatured hemoglobin that precipitates within the red blood cells, making them appear as small, dark inclusions. However, the conventional Wright stain does not adequately demonstrate them because they require a specific staining procedure, such as the use of a supravital stain (like new methylene blue), to visualize effectively.

Understanding the visibility of different red blood cell inclusions with various stains is important in hematology, as it can help in diagnosing diseases. Howell-Jolly bodies, basophilic stippling, and reticulocytes can all be observed with a Wright stain, making the distinction of Heinz bodies significant in a clinical setting.