Which RBC shows a peripheral rim of hemoglobin with a dark staining central area?

The correct choice focuses on the characteristic morphology of certain red blood cells. A leptocyte, also known as a target cell, typically exhibits a peripheral rim of hemoglobin that gives it a distinct appearance, resembling a target. This morphology results from a relative increase in surface membrane area compared to the volume of hemoglobin within the cell, which creates a central area that appears darker due to the concentration of hemoglobin.

Leptocytes are often associated with various conditions, including liver disease and hemoglobinopathies, and their unique morphology aids in their identification during microscopic evaluation of blood smears. The presence of a pale central area surrounded by the hemoglobin-rich rim is the hallmark feature that defines a leptocyte.

Understanding these features helps in diagnosing and monitoring various hematological conditions, making recognition of such cellular characteristics crucial for accurate interpretation of blood smears.