Which statements are consistent with toxic granulation of neutrophils?

Toxic granulation of neutrophils is characterized by the presence of darker staining granules within the cytoplasm of neutrophils. This phenomenon can occur as a response to severe infections, inflammation, or other stressors.

The correct statement about toxic granulation is that it may be accompanied by Dohle bodies. Dohle bodies are light blue cytoplasmic inclusions that often appear in neutrophils during conditions of inflammation or infection. Their presence alongside toxic granulation is indicative of a reactive process within the leukocytes due to heightened immune activity. The overlapping presence of these features can help pathologists and clinicians understand the underlying condition affecting the patient.

Considering the other statements, they either reference conditions or features that are not typically associated with toxic granulation or conflict with established hematological knowledge. For example, the presence of Auer rods typically indicates myeloid lineage or acute myeloid leukemia, which is a distinct condition from the reactive process of toxic granulation. Toxic granulation is indeed observed in various types of infections, including viral infections, making the assertion that it is not found in such cases inaccurate. Additionally, toxic granulation is often associated with an elevated white blood cell count as the body mounts a defense against infection or injury,