Which type of cells are commonly seen in chronic lymphocytic leukemia?

In the context of chronic lymphocytic leukemia (CLL), smudge cells, also known as "smear" or "basket" cells, are characteristic and commonly observed. These cells are formed when fragile lymphocytes break apart during the preparation of blood smears, resulting in a distinct appearance where the nucleus is smeared out and not intact. The presence of smudge cells is often used as a key indicator in the diagnosis of CLL, as they reflect the underlying pathology associated with the disease.

Smudge cells are found due to the increased number of small, mature lymphocytes in the blood typical of CLL, with these cells being particularly susceptible to damage during slide preparation. Observing these cells can provide important visual clues to laboratory personnel when diagnosing and monitoring this type of leukemia. Understanding the significance of smudge cells assists in the overall approach to hematological assessments, making them a critical focus in learning and practice for medical technologists.