Wiskott-Aldrich is a qualitative platelet disorder that is associated with which one of the following?

Wiskott-Aldrich syndrome is indeed associated with a qualitative platelet disorder wherein patients typically exhibit problems related to the function of platelets, particularly regarding their aggregation response. In this syndrome, one of the hallmarks is abnormal secondary aggregation.

Secondary aggregation refers to the process where platelets, after an initial stimulus causing them to change shape or become activated, aggregate more effectively in response to additional stimuli, often mediated by physiological agonists like ADP or thromboxane A2. In individuals with Wiskott-Aldrich syndrome, the ability of platelets to complete this secondary aggregation is impaired, leading to a tendency for bleeding due to insufficient platelet plug formation.

This dysfunction can be linked to underlying issues such as the deficiency of specific proteins that play vital roles in platelet activation and aggregation. The abnormal response to aggregation agents ultimately distinguishes this condition from other qualitative disorders.

Understanding this incorrect platelet function is crucial in managing Wiskott-Aldrich syndrome, as it helps guide treatment options and anticipates complications associated with the disorder.